Infections due to Clostridium difficile, MRSA or VRE: Clinical and System Reviews, Incident Analyses
In addition to surveillance and outbreak investigation a system review maybe indicated to identify potential causes of outbreaks and determine appropriate recommendations.
Occurrences of harm are often complex with many contributing factors. Organizations need to:
- Measure and monitor the types and frequency of these occurrences.
- Use appropriate analytical methods to understand the contributing factors.
- Identify and implement solutions or interventions that are designed to prevent recurrence and reduce the risk of harm.
- Have mechanisms in place to mitigate consequences of harm when it occurs.
To develop a more in-depth understanding of the care delivered to patients, chart audits, incident analyses and prospective analyses can be helpful in identifying quality improvement opportunities. Links to key resources forÌýconducting chart auditsÌý²¹²Ô»åÌýanalysis methodsÌýare included inÌýHospital Harm Improvement Resources Introduction.ÌýÌý
If your surveillance, outbreak investigation or system review reveals that your cases ofÌýC.Ìýdifficile, MRSA or VRE are linked to breaks in infection prevention and control practices, these resources maybe helpful:ÌýÌý
Organizations
Canadian
- Infection Prevention and Control Canada: Resources and PublicationsÌý
- Provincial Infection Control Network of British Columbia (PICNet): Guidelines and ToolkitsÌý
- Public Health Agency of Canada, Infection Control Guideline SeriesÌýÌý Ìý
- Public Health Ontario: Infection Prevention and ControlÌý
International
- World Health Organization: Infection Prevention and ControlÌý
- Association for Professionals in Infection Control and Epidemiology: Practice guidance for infection preventionÌý
- Centers for Disease Control and Prevention (CDC) : Infection ControlÌý
Infection Prevention and Control Programs
Canadian
- Government of Manitoba. Routine practices and additional precautions: Preventing the transmission of infection in health care.ÌýWinnipeg, MB: Government of Manitoba; 2012. Available at:ÌýÌý
- Health Quality Ontario.ÌýImprovement map: Infection prevention and control.ÌýAvailable at:ÌýÌý
- Provincial Infectious Diseases Advisory Committee (PIDAC).ÌýBest practices for infection prevention and control programs in Ontario.ÌýToronto, ON: Public Health Ontario; 2012. Available at:
International
- National Institute for Health and Care Excellence (NICE).ÌýHealthcare-associated infections.Ìý2016. Available at:Ìý
- NICE.ÌýInfection prevention and control. 2014. Available at:Ìý
- World Health Organization (WHO). Guidelines on core components of infection prevention and control programmes at the national and acute health care facility level. 2016. Available at Ìý
Routine Practices and Additional Precautions
Canadian
- Public Health Agency of Canada (PHAC).ÌýRoutine practices and additional precautions for preventing the transmission of infection in healthcare settings.Ìý2017. Available at:Ìý
- Provincial Infectious Diseases Advisory Committee (PIDAC). Routine practices and additional precautions in all health care settings. Public Health Ontario; 2012. Available at: Ìý
Hand Hygiene
Canadian
- Health Quality Ontario.ÌýImprovement map: Hand hygiene.ÌýAvailable at:Ìý
- Provincial Infectious Diseases Advisory Committee (PIDAC).ÌýBest practices for hand hygiene in all health care settings.Ìý4thÌýEd. Toronto, ON: Public Health Ontario; 2014. Available at: Ìý
International
- Centers for Disease Control and Prevention (CDC).ÌýHand hygiene guideline.ÌýCDC; 2002. Available at:Ìý
- World Health Organization (WHO).ÌýWHO guidelines on hand hygiene in health care.ÌýGeneva; WHO: 2009. Available at:Ìý
Best Practices in Environmental Cleaning
Canadian
- Provincial Infectious Diseases Advisory Committee (PIDAC).Ìý. Toronto, ON: Public Health Ontario; 2018. Available at:ÌýÌýÌý
- Provincial Infection Control Network of British Columbia (PICNet). British Columbia best practices for environmental cleaning for prevention and control of infections in all healthcare settings and programs. Vancouver, BC: PICNet; 2016. Available at:Ìý
International
- Centers for Disease Control and Prevention (CDC).Ìý.ÌýCDC; 2016. Available at:Ìý
Best Practices in Hospital Surveillance and Screening for Patients at High Risk for Presence of MRAS and/or VREÌý
Canadian
- Canadian Agency for Drugs and Technologies in Health (CADTH).ÌýMethicillin-resistant Staphylococcus aureus (MRSA) screening and discontinuation of precautions in hospitals: Clinical effectiveness and guidelines.ÌýCADTH; 2011. Available at:Ìý
- Provincial Infectious Diseases Advisory Committee (PIDAC).ÌýBest practices for surveillance of health care-associated infections. Toronto, ON: Public Health Ontario; 2014. Available at: Ìý
- Provincial Infectious Diseases Advisory Committee (PIDAC).ÌýAnnex A: Screening, testing and surveillance for antibiotic-resistant organisms (AROs).ÌýToronto, ON: Public Health Ontario; 2013. Available at: Ìý
International
- Lee TB, Montgomery OG, Marx J, Olmsted RN, Scheckler WE. Recommended practices for surveillance: Association for Professionals in Infection Control and Epidemiology (APIC).ÌýAJIC.Ìý2007; 35: 427-440. doi:10.1016/j.ajic.2007.07.002. Available at:ÌýÌýÌý
Best Practices for Outbreak Management
Canadian
- Population and Public Health Division, Ministry of Health and Long-Term Care.ÌýInstitutional/facility outbreak management protocol, 2018.ÌýGovernment of Ontario; 2018.Ìý Available at:ÌýÌý
- Provincial Infectious Diseases Advisory Committee (PIDAC).ÌýAnnex C: Testing, surveillance and management of Clostridium difficile in all health care settings.ÌýToronto, ON: Public Health Ontario; 2013. Available at: Ìý
International
- Campbell, EA. Chapter 12: Outbreak investigations.ÌýÌýAPIC Text of Infection Control and Epidemiology.ÌýReston, VA: APIC; 2014.ÌýÌý
- Centers for Disease Control and Prevention (CDC). Healthcare-associated infection (HAI) outbreak investigation toolkit. CDC; 2013. Available at:
- World Health Organization (WHO).Ìý. Geneva; WHO: 2014. Available at:Ìý
Antimicrobial Stewardship
Canadian
- Do Bugs Need Drugs?Ìý
- Nakamachi Y, West S, Dresser L, Morris AM. Developing and expanding hospital antimicrobial stewardship: The Ontario experience.ÌýCCDR Suppl.Ìý2015; 41S-4. https://doi.org/10.14745/ccdr.v41is4a04. Available at:Ìý
- Public Health Ontario.ÌýAntimicrobial stewardship.ÌýAvailable at:Ìý
International
- Centers for Disease Control and Prevention (CDC).ÌýCore elements of hospital antibiotic stewardship programs.ÌýCDC; 2017. Available at:Ìý
Interagency Coordination Group on Antimicrobial Resistance (IACG).Ìý. World Health Organization; 2018. - National Institute for Health and Care Excellence (NICE).ÌýAntimicrobial stewardship. NICE Quality Standard; 2016. Available at:Ìý
- NICE. Antimicrobial stewardship: Systems and processes for effective antimicrobial medicine use.ÌýNICE Guideline; 2015. Available at:ÌýÌý
Best Practices for IPAC for Clostridium difficile (C. difficile), MRSA and VRE
Canadian
- Health PEI.ÌýPrince Edward Island infection prevention and control methicillin-resistant staphylococcus aureus (MRSA) guideline.ÌýPrince Edward Island Department of Health and Wellness; 2016. Available at:ÌýÌý
- Prince Edward Island (PEI) Department of Health and Wellness.ÌýProvincial vancomycin-resistant enterococci (VRE) guideline.ÌýPEI Department of Health and Wellness; 2009. Available at:Ìý
- Provincial Infection Control Network of British Columbia (PICNet). Antibiotic resistant organisms prevention and control guidelines for healthcare facilities.ÌýVancouver, BC: PICNet; 2013. Available at:Ìý
- Provincial Infectious Diseases Advisory Committee (PIDAC).ÌýReview of literature for evidence-based best practices for VRE control. Toronto, ON: Public Health Ontario; 2012. Available at:ÌýÌý
- Public Health Agency of Canada (PHAC).ÌýClostridium difficile infection: Infection prevention and control guidance for management in acute care settings. Ottawa, ON: PHAC; 2013. Available at:Ìý
International
- Association for Professionals in Infection Control and Epidemiology (APIC).Ìý, 2ndÌýEd. Washington, DC: APIC; 2010. Available at:Ìý
Patient Education and Engagement
Canadian
- Patient Engagement Action Team. 2017.ÌýEngaging Patients in Patient Safety – a Canadian Guide.ÌýCanadian Patient Safety Institute. Last modified February 2018. Available at: /en/resources/engaging-patients-in-patient-safety-a-canadian-guide/
- ÈÕ±¾ÎÞÂë. Hand hygiene: Working with patients and families. Edmonton, AB: CPSI; 2016.
International
- Centers for Disease Control and Prevention (CDC).Ìý.ÌýCDC; 2016. Available at:Ìý
- CDC.Ìý.ÌýCDC; 2015. Available at: Ìý
Ìý